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Ocetreotide, Acetate

Octreotide acetate

CAS: 83150-76-9

Molecular Formula: C49H66N10O10S2

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Ocetreotide, Acetate - Names and Identifiers

Name Octreotide acetate
Synonyms ctreotide
DARAMONOL
OXTREOTIDE
OctreotideAcetate
Octreotide acetate
Ocetreotide, Acetate
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl-, cyclic (2?7)-disulfide
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-19-(D-phenylalanylamino)-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carboxamide
CAS 83150-76-9
EINECS 1533716-785-6
InChI InChI=1/C49H66N10O10S2.C2H4O2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41;1-2(3)4/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64);1H3,(H,3,4)/t28-,29-,34-,36+,37+,38-,39-,40+,41+,42+;/m1./s1
InChIKey DEQANNDTNATYII-MEUDYGGUSA-N

Ocetreotide, Acetate - Physico-chemical Properties

Molecular FormulaC49H66N10O10S2
Molar Mass1019.24
Density1.39±0.1 g/cm3(Predicted)
Melting Point>140°C (dec.)
Boling Point1447.2±65.0 °C(Predicted)
Flash Point829.053°C
Solubility Soluble in acetic acid, DMSO, and methanol
Vapor Presure0mmHg at 25°C
AppearanceSolid
ColorWhite to Off-White
pKa12.60±0.70(Predicted)
Storage Condition-20°C
StabilityHygroscopic
Refractive Index1.673
Physical and Chemical Properties[Α] D20-42 °(C = 0.5,95% acetic acid).
UseCan inhibit growth hormone, inhibit gastrointestinal pancreas secretion of polypeptides
somatostatin analogs in the treatment of acute esophageal venous hemorrhage and acromegaly.

Ocetreotide, Acetate - Risk and Safety

WGK Germany3

Ocetreotide, Acetate - Reference

Reference
Show more
1. Cai Zhiyuan Wang tangles Guo Huailiang et al. Effects of two chemical drugs on behavior and physiology of plateau zokor [J]. Sichuan Animal 2020(4):375-384.

Ocetreotide, Acetate - Nature

Open Data Verified Data

This product is a synthetic octapeptide analog of somatostatin. It shares with native somatostatin the 4-peptide sequence required for activity as a promoter (benzene, chromogen, Lai, Su). However, because octreotide includes two D-amino acids and a deformed threonine, it is more resistant to degradation by plasma peptidases and has a longer half-life (about 30-fold) than growth inhibition. The pharmacological effects of this product is similar to that of natural somatostatin, which can inhibit serotonin, vasoactive intestinal peptide (VIP), insulin, glucagon, secretin, actin and pancreatic polypeptide. It is more selective than natural growth inhibition for inhibition of growth hormone secretion and less effective for insulin release. The effect of octreotide on susceptible target tissues may be mediated by its effect on the cell surface somatostatin receptor promoter. Half-Life of 1.5 h.

Last Update：2024-01-02 23:10:35

Ocetreotide, Acetate - Use

Open Data Verified Data
  • for the control of symptoms of metastatic carcinoid and vasoactive intestinal peptide-secreting adenocarcinoma; Treatment of acromegaly, pancreatic fistula, tumor hormone Diarrhea peptide hormone secretion disorders, non-neoplastic Diarrhea, treatment of diarrhea syndrome that occurs after gastrectomy.
  • usage and dosage of metastatic carcinoid, 100 ug daily for the first two weeks, divided into 2 to 4 times. Some patients with carcinoid tumors have 1. 5mg daily. For adenocarcinoma (VIP), 200 ~ 300ug daily for the first two weeks. All were injected subcutaneously.
  • each 0. 05mg/mL, 0.1 mg]mL, 0.5mg/mL.
Last Update：2022-01-01 11:11:41

Ocetreotide, Acetate - Safety

Open Data Verified Data

The side effects of this product are Abdominal Pain, abdominal distension, Diarrhea, steatorrhea; Gallstone formation; Glucose tolerance may decrease or worsen in the early stage of treatment, and then can be improved; Long-term application without endogenous antibody production, there was no obvious rebound or adverse reaction when the drug was stopped or rapidly reduced. 2~8 deg C for long-term storage.

Last Update：2022-01-01 11:11:41
Ocetreotide, Acetate
Supplier List
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Multiple Specifications
Product Name: Octreotide Ditrifluoroacetate Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Octreotide Visit Supplier Webpage Request for quotation
CAS: 83150-76-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Multiple Specifications
Product Name: Octreotide Ditrifluoroacetate Request for quotation
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Shanghai Yuanye Bio-Technology Co., Ltd.
Spot supply
Product Name: Octreotide Visit Supplier Webpage Request for quotation
CAS: 83150-76-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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Ocetreotide, Acetate
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